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1. Residual distance (r) : We measure the similarity between two sequences, for instance the reconstructed data ( Ŝ 1 ) and the original uncorrupted data (S 1), by measuring the normalized Euclidean residual distance.

where (overline {c_{X}}=sum _{i=1}^{N} c_{X_{i}} / N) and (overline {c_{Y}}=sum _{i=1}^{N} c_{Y_{i}} / N) are the mean values of c X and c Y. A strong correlation occurs between two sequences for C P ≃±1, and no correlation exists for C P ≈0.

Pairwise LD for idh was calculated as r2 between all SNPs pairs (Figure 1B), and nucleotide diversity, π, the average number of nucleotide differences per site between two sequences, for CCM genes was estimated using the TASSEL software [45].

The number of changes between two sequences for each gene was calculated by taking the product of the substitution rate per site (d N and d S) and the number of sites (N or S bases).

However, all of those cases corresponded to positions where adjacent reads overlapped by only ~25nt, the specified minimum overlap allowed between two sequences for collapse into a contig for our assembly (see Materials and Methods; Figure 4B, positions ~23k, ~54k, ~88k, ~91k, ~94k).

Nucleotide diversity was calculated as the average number of nucleotide differences per site between two sequences for both, the complete sequences and restricted to exons, and haplotype diversity (Hd) as the probability that two randomly chosen haplotypes from a given population were different [ 37].

Similar(54)

DTW finds an optimal match between two sequences that allows for compressed sections of the sequences.

The average number of nucleotide substitutions per site between two sequences, π was calculated for each gene as well as the haplotype diversity.

On a few occasions, recombination between two sequences was the best explanation for incompatible motifs in an alignment.

Moreover, the e-value that is a parameter related to the reliability of the similarity between two sequences is expected to be very low for specific matches.

Expected-value (E-value or E), sequence identity and bit scores were collected for evaluating the similarity between two sequences.

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