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The following procedure was used to quantify functional similarity between two proteins according to SSBP: First, identify all gene ontology terms shared by two proteins; next, count how many other proteins were assigned to each of the shared terms as well; finally, identify the shared biological process term with the smallest count (SSBP).
Next we weighted the interaction between two proteins according to the weight function: W (x, y ) = n 1 (|| x - K x || 2 + || y - K y || 2 )+ n 2|| K x - K y || ||·|| stands for the distance metric and there are many metrics for measuring it, in this study we have used Euclidean distance.
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Most of all, only the pairwise binary interactions between two proteins are considered in PPI, and they are not sufficient to capture real biological processes involving a stable form of proteins grouped according to their biological functions.
Moreover, analysis is performed of the kinetics of protein-protein interactions at physical contacts that are established between two proteins, owing to biochemical events, protein affinity adsorption forces, and protein binding forces.
PNAC considers five distinct features to classify proteins according to their degree of nucleolar association: The frequency of most individual amino acids does not differ significantly between the proteins of the different nucleolar-association training set groups.
These two proteins to be discussed are one-domain proteins according to Pfam.
We group proteins according to any detectable homology between sequences - that is, according to the uniqueness of their sequence in the protein sequence space.
The above introduced cross-entropy measure is used to compare the topology strings of two proteins resulting in finding the initial overlap between two structures according to a task described below.
This suggests that the epistatic interaction between the two SNPs may play a role in the interaction between the two proteins.> Many of the SNP-associated genes in Table 6 are highly related to oil content according to the literature.
These favorable interactions stabilize the association between the two proteins.
Colocalization between the two proteins was observed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com