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Cumulative exposure was estimated by summing the durations of all bisphosphonate prescriptions for each patient, considering gaps of fewer than 90 days between two prescriptions as continuous therapy.
If a gap of more than 77 days was observed between two prescriptions it was assumed that the drug had been paused or seponated 24.
For our main analyses, we added the days between prescriptions; if days between two prescriptions was >6 months, then the days counted for the earlier prescription was limited to 183.
If there was an overlap between two prescriptions of the same drug at the same dose and schedule, we assumed that the first prescription was finished before the second prescription was started rather than assuming a higher amount of drug was taken during the overlap.
When there was a gap of 7 days or less between two prescriptions of the same drug, or of different drugs within the same drug class (excluding DMARDs), it was assumed that the drug was taken continuously and the gap was filled with the daily dose of the second prescription.
A gap of maximal 6 months was chosen because in daily practice patients rarely collect a subsequent prescription exactly on the day their supply of their previous prescription has ended, normally 90 days, but rather earlier (overlap of two prescriptions) or later (gap between two prescriptions).
Similar(54)
Instead of the Blue vs. the Gray, we have a scorched-earth war between two prescription-drug plans.
The most common potentially adverse interaction between two prescription drugs was with the blood pressure drug amlodipine (Norvasc) and simvastatin (Zocor), which lowers cholesterol.
Refill compliance during the interval between two prescription fills was calculated as the number of days for which the pills were prescribed divided by the total number of days in this interval.
About three quarters of all Americans over 65 have two or more chronic conditions and many take between four and eight prescription drugs.
Between the two prescriptions, I made a discovery that changed my life for the better.
More suggestions(17)
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