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Additionally, in some situations, greater precision of a population genetic parameter estimate can be achieved by sampling both shared polymorphisms and fixed differences between two populations, which can only be observed by sampling loci that have different genealogies [e.g. 13].
In this paper, we used a model similar to that of Telschow et al. [ 28] to investigate how CI contributes to maintaining divergence between two populations which have undergone different selection regimes, but after which nuclear genes and Wolbachia can be exchanged.
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It follows that there was certainly contact between the two populations, which may have permitted both cultural and genetic exchanges.
Thus, the demographic differences between the two populations, which affect mating behaviour and phenotypic plasticity, likely stem from different ecological features of these two distinct habitats.
There are clear differences in survival between these two populations which reflect variations in severity of cancer, possibly resulting from policy and practices regarding screening and treatment, cancer biology, and cancer registration.
Although our population and the population described by Guo et al. [ 7] are both interspecific populations, a different polymorphism was found between the two populations, which might result from different materials or different genotyping methods (denatured polyacrylamide gel vs. non-denatured polyacrylamide gel).
In the case of population stratification, the penetrance is quite high and the effect size is related to the allele frequency difference between the two populations, which is often several fold higher than the 2.5 odds ratio of the simulated dataset.
This small difference is presumably due to the high correlation between the MAF of SNPs in the two populations, which was equal to 0.91 for ECA1 and 0.90 for ECA26.
This study also revealed differential patterns of gene expression in hybrid crosses between these three populations which indicated that each of them harbors a unique genetic architecture (Bougas et al. 2010).
Thus, one is comparing outcomes between two populations in which measured systematic differences between treatment and control groups have been eliminated.
In fact, a preliminary analysis with all the 12 samples available (including both the samples we collected and those of Ref. [ 5]) indicated the absence of genetic differentiation between two White Karen and between two Lahu populations, which were therefore pooled bringing the total number of populations to 10.
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