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The weighted kappa for CC categorization between two observers was 0.8980 (95% confidence interval: 0.8638 0.9322).

The F-test between two observers was not statistically significant for each MR imaging set.

The variation between two observers was less than 4% during the training period.

Inter-observer agreement between two observers was measured by mean difference and general limits of agreement [ 21].

The intraclass correlation coefficient (ICC) (95%% confidence interval (CI)) between two observers was calculated for both PET and MRI cumulative scores.

Similar(55)

If the difference between two observers were greater than 10%, a consensus was achieved.

Because three other tumors were judged differently by two observers and the average of the two judgments was within the range of equivocal, they were subjected to a re-count: for two tumors, the second judgments also differed between two observers, being positive and equivocal respectively, but the average of the judgments of HER2/ CEP17 ratio exceeded 2.20, so they were finally judged positive.

For the RV data of 3DE, the relative differences between two observers were found to be 11% for EDV, 13% for ESV, 9% for SV and 1% for EF (Table  3), respectively with little but significant difference only for ESV and very good correlation (R > 0.7) for EDV and ESV, and less good correlations for EF (R = 0.58) and SV (R = 0.26).

Reproducibility of the scoring method between three observers was greater than 90%.

The inter-observer reliability between three observers was high: The mean Pearson correlation coefficient for the estimation of looking time for 3 observers for a subset of randomly selected looking events was 0.998 (N = 27 trials).

The intra-class correlation coefficient (ICCs) of the T1ρ values between the two observers was 0.93 (95% CI = 0.84 0.95), indicating good agreement between the observers.

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