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The Jaccard similarity between two lists is defined as the ratio between the size of the intersection and the size of the union of the two lists.
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But the biggest difference between the two lists is this: The IRS measures annual income, while Forbes calculates net wealth.
Interestingly, the overlapped genes between the two lists is 1105 genes (25.2%) (Additional File 2).
The concordance between the two lists is calculated as the number of genes in common divided by the number of genes in the input list.
Genes in common between these two lists were uploaded to WebGestalt for Gene Ontology (GO) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis [ 17, 18].
Heterogeneity between individuals means that even if two lists are independent within individuals, the two sources may become dependent if the capture probabilities are heterogeneous among individuals.
Once the two lists are done, draw some comparisons between them.
Concordance between each pair of the five lists is shown in Table 3.
Still, the only overlap between the three lists was CYP24, DUSP10, AKAP12, P2RY2, BMP6, TGFB2, and TXNRD1.
The magnitude of the overlap between two gene lists was evaluated as the ratio of the intersection over the union of the two lists.
All tests for significant overlap between two gene lists were done in R using the one-sided Fisher's exact test for enrichment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com