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In Kriston and colleagues' multiple interventions meta-analysis of psychotherapeutic treatments for acute depressive disorder, conflict between two large trials testing the combination of cognitive behavioural therapy and medication accounted for most of the heterogeneity in their network of evidence [ 24].
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Nonetheless, two large trials have previously reported a null association between CYP2D6 genotype and breast cancer outcome [ 27, 28], which appears to contradict our findings.
But in this case, AstraZeneca recently announced that two large trials had shown no increased survival.
Characterization of myocardial infarction as an end point in two large trials of acute coronary syndromes.
Two large trials have recently been published.
Secondary analyses of data between two large clinical trials to reduce the incidence of stroke – the Systolic Hypertension in Europe (SYST-EUR) trial (involving the ACE-I enalapril) and the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) trial (involving the ACE-I perindopril) – found that the ACE-Is reduced dementia and cognitive decline [ 8].
Two larger trials in adults showed the opposite result.
This was despite evidence from three large trials suggesting equivalence between the treatments and several additional factors apparently favoring oral amoxicillin including lower cost, more convenient twice daily dosing and reduction in the use of injections in children.
Divide them between two large plates.
Downtown Madison is situated between two large lakes, Lake Mendota and Lake Monona.
The similarity in results between these two large observational trials is striking.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com