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Interaction between two genes is mediated by gene products.
A natural distance between two genes is the distance between their corresponding natural vectors.
Quantifying the functional relatedness between two genes is not trivial; often existing information about gene function are exploited to infer functional relationships among genes.
However, the ability to demonstrate interactions between two genes is restricted to those that result in a measurable change in phenotype, such as fitness.
In the context of synthetic lethal interaction data alone, the global similarity of synthetic lethal interaction patterns between two genes is used to predict gene function.
This approach helps discard spurious correlation co-efficients i.e. arrangements where a large proportion of the correlation between two genes is actually attributable to the presence of a third gene.
Similar(19)
Intergenic distance between two genes are defined as the closest distance between them, using 5' or 3' end.
Each gene loci is a range of base pairs and the distance between two genes was defined as the head to tail distance except when a miRNA is in the intron of an mRNA.
The remaining inter-gene variants between two genes were grouped together.
Sequence identity between two genes was determined using the bl2seq tool [ 58].
The shortest paths between two genes were computed using Dijkstra's algorithm (Dijkstra, 1959).
More suggestions(19)
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