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Presence of a multiplicative and absence of an additive interaction among two correlated genes has been already described [20] and probably reflects the complexity of the interaction between two genes in multifactorial diseases.
Here we designed the "covariability" measure to model regulation strength between two genes in each sample.
35 cases of protein-protein interaction between two genes in the same cluster were found.
Network Edges: A list of connections between two genes in the networks shown in Figure 7.
We then examine the significance of the interaction in expression between two genes in terms of classes of another gene.
A breakpoint is a disruption of the genome sequence order, i.e. when adjacency between two genes in one genome disappears in another one.
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The likelihood of an overlap between three genes in these two studies has a P-value of<0.05, as calculated using hypergeometric statistics.
The predicted domain-domain based protein interaction network identified interactions between three genes in the candidate list with cyclins, depicting the possibility that the genes could regulate the cell cycle indirectly by relaying regulatory messages.
Note that the distance between two genes used in this article is the difference their ranks on the chromosome (approximately equivalent to the number of kb).
The mean difference in rank between two genes is calculated in the event of ties between equivalently accurate classifiers as described previously [ 22].
The experiments showed that cohesin, Hop1, and Red1 are enriched in regions between two genes that run in the opposite directions to each other.
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