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For example, Erkan et al. (2007) used the shortest path between two genes according to edit distance in a dependency tree to define a kernel function for extracting gene interactions.
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For Tas1r1- 2 and Pkd2l1, based on the assumption that all branches had a single ω value, purifying selection was seen across the tree for the three genes according to comparison between model A and model B (ω = 0.2919, p = 0; ω = 0.20585, p = 0; ω = 0.28788, p = 0; respectively).
Using one million permutations, we randomly placed mutations within each of the three genes according to the number observed, calculating the distance in bases between the two furthest mutations.
Analysis of microarray data for co-expression between two genes was performed according to the method reported before [ 45].
Duplicate genes were defined according to criteria that the alignable region between two genes is longer than 50% of both genes and the E-value is less than 10−10.
They found a link between obesity and a short section of the genome that lies between two genes.
The subjects of a new Finnish study who helped establish the link between two genes and violent crime were an especially savage bunch.
Interaction between two genes is mediated by gene products.
In the closely related species M. roreri, a 14 Kb area between nad3 and nad1 was found with five ncORFs and two putative plasmid genes (according to our criteria) (Costa et al. 2012).
Hierarchical clusterization is a holistic approach based on the calculation and comparison of pairwise correlation coefficients between two datasets to arrange genes according to similarity or closeness in expression pattern [47].
This led to a clear separation between the two compartments and identified clusters of genes according to the stage of follicular development, suggesting a difference in the dynamics of transcription between oocytes and GCs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com