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The bomb exploded as the cars were passing between two checkpoints run by Iraqi soldiers.
Between two checkpoints, at the campus border, Jarecki's driver managed to position himself in the lane reserved for trucks: a harmless mistake, or so it seemed, until he lowered his window and asked for directions to Lincoln Hall (otherwise known as the Combating Terrorism Center).
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If I ran between the two checkpoints five or six times, I could make five miles.
We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between these two checkpoints.
This observation suggests there is some functional overlap between the two checkpoint effector kinases.
However, the early lethality of Chk1-deficient mice and severe checkpoint deficits in derived ES cell cultures argues against a significant degree of redundancy between these two checkpoint pathways in vivo.
Once the model is constructed, the problems allow the students to use Manipulate to visualize how the cell moves between two molecular checkpoints (i.e., two stable equilibrium points).
"I only hit two checkpoints," Brian Lorei told me afterwards.
For simplicity, only two checkpoints steps are considered here.
The rules of the race require a mandatory 12 hours of rest to be divided between the four checkpoints along the trail.
Exactly how the substrate binds into this receptor is not yet clear, but the interactions between Cdc20 and two checkpoint proteins in the structure of the Mitotic Checkpoint Complex (Chao et al., 2012) indicate that a KEN-box can bind to the top surface of Cdc20.
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