Given the low probability of a switch, two switches in such closely related cells implied there was either perdurance of the Cre protein following a single loss-of-silencing event, or some 'heritable' instability shared between these two cells, as has been previously suggested in a different context (Kaufmann et al., 2007).
The number of links between two cells was set as k = 4, and the initial population of type A and type C cells were set as 9900 and 100, respectively.
For a given TF, when calculating the variation score for a histone mark, the maximum Euclidean distance between two cells was used as the histone variation score for the TF.
From an engineering perspective, these QS systems can be decomposed into two separate modules with one for signal production and the other for signal detection and response - when engineered in different cells, the two functional modules will confer communications between the two cells as shown in Figure 1C.
Cross-correlation between two cells' spiking activities was computed as a normalized spike count correlation.
For example with the cellular Potts model, the number of lattice boundaries shared between two cells is counted and included as a term in the model's energy function.
In the second situation (referred to as the Homo preference [Hm]), the preferred gaps are selected in the following order: (1) gaps between a cell of the same cell type as the cell in question and a cavity, (2) gaps between two cells of the same cell type as the cell in question, and (3) gaps between a cell of the same cell type as the cell in question and a cell of a different cell type.
In the first situation (referred to as the Hetero preference [Htr]), the preferred gaps are selected in the following order: (1) gaps between a cell of the same type as the cell in question and a cavity, (2) gaps between a cell of same cell type as the cell in question and a cell of a different cell type, and (3) gaps between two cells of the same cell type as the cell in question.
A parameter W ij (known as weight) is associated with each connection between two cells.
In normal squamous epithelium, E-cadherin beta-catenin complE-cadherin beta-cateninaintaining thE-cadherin beta-catenin juncomplexestween two areacent cells, as well as the barrimportantiny of the epitheliumaintaining
