Variables m18 (denoting the concentration of 1°) and m30 (denoting the concentration of 2°) are regarded as two cell fate candidates for determining final VPC fate.
Six cell fates of Pn.p cells comprise a cell fate pattern in the form of [P3.p P4.p P5.p P6.p P7.p P8.p].
In addition, Notch signalling has been shown to play an important role in defining the two different cell fates that result from asymmetric cell divisions, and in inductive signalling events that cause cells to adopt a specialised cell fate at the boundary between two cell populations (reviewed in [ 22]) (Fig. 2b,2c).
However, focusing our study on the early transcriptional events of a specific biological process that occurs under defined in vitro conditions allowed us to identify a few changes in gene expression, including that of Myc, that discriminate between the two opposing cell fates.
We identified functional differences between oocytes and GCs and described the characteristics of each compartment that lead to two specific cell fates.
As genetic programs are influenced by external factors the search continues not only into genetic determinants but also extrinsic influences and the interplay between the two in cell fate specification.
Interestingly, transforming growth factor-β is not only required for generation of Th17 cells but also for the generation of Tregs, at least in the periphery, and so it is the presence or absence of IL-6 that decides between the two T-cell fates.
Furthermore, promoters for these three genes drove reporter expression in all somatic cells in the early embryo [ 39], an odd expression pattern for a transcription factor that is expected to function in distinguishing between developmental cell fates.
Specifically, we present two prevalent perspectives on the forces shaping social interactions between cell fates — engineering optimality and social stability — and review recent works combining engineering, developmental and social evolution analyses in light of this distinction.
The latest capacity allowed us to test two different bone cell fates originating from the same cell type.
