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Moreover, it is nearly impossible to design non-invasive experiments that target and/or alter a particular connection between two brain regions.
Second, the value of connectivity between two brain regions we calculated by probabilistic fiber tracking method does not necessarily indicate that there is an actual fiber which connects the two regions directly.
Coherence is a measure of "coupling" or functional association between two brain regions (Nunez 1981 , 1995.
PPI is used to access the physiological connectivity between two brain regions that is also varied with the psychological context [Friston et al., 1997].
We highlight the fact that the presented models are not meant to replace manual and individual evaluation of the connectivity between two brain regions.
A natural step in this analyses could be the construction of gene co-expression networks using the union of the DE genes between two brain regions.
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The current dataset provides a comparison between two brain region tissues only and is therefore somewhat limited in its perspective.
Overall, we find that mean expression levels are weakly preserved between three brain regions and blood (r range [0.24,0.32]).
A linear mixed effect model was used to jointly analyze the 48 samples, while accounting for the correlations between three brain regions of each mouse.
We used the detection status of all 22 184 probes represented on the Illumina HumanRef-8 version 2 chip across the tissues sampled in tissue set one to determine relationships in gene expression between eight brain regions.
Both measures (SRC and PV) for the whole brain and blood data set are available on the Integrated Vervet Monkey Genomics website: http://genomequebec.mcgill.ca/compgen/submit_db/vervet_web, which enables searches for similarities of expression profiles between eight brain regions and blood for specific genes.
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