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The "Optional parameters setting" panel contains three more input parameters: "Overlap": a value between 0 and 1, denoting the maximum allowed fraction of common nodes between two alignments, in order to be considered distinct.
The level of agreement between two alignments can be assessed using the Column Score [ 29], which measures the percentage of the columns of residues in the test alignment which agree with the columns in the reference alignment.
When the distance between two alignments on the same chromosome was short, the genomic sequence was further analyzed by dot plot to identify any potential continuity between the two alignments.
Similar(56)
If a region between two alignment ends is 10 residues or shorter, we extend the two domain boundaries to fill the region.
We used the Pearson's correleration coefficient to measure the similarity between two alignment profiles.
We differentiate between two alignment problems, depending on whether strict constraints on protein matches are given, based on sequence similarity, or whether the goal is instead to find an optimal compromise between sequence similarity and interaction conservation in the alignment.
SNV concordance for a single exome, "k8101-49685", between five alignment and variant detection pipelines: GATK, SOAPsnp, SNVer, SAMtools, and GNUMAP.
Only 120 of the 33.6 million (0.0003 %) reads were aligned differently between the two alignments.
The degree of agreement between these two alignments may be used to assess the reliability of the sequence alignment.
To emphasize, overlapping denotes some coverage of common sequence ranges between the two alignments for the same domain model.
The second is a Genomic Distance Penalty (GDP) calculated as log10 of the number of base pairs along the reference genome between the two alignments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com