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Our findings confirm the usefulness of our strategic approach for investigating response rate, data quality and measurement equivalence between two administration methods during early PRO instrument development or in limited samples where recruitment to large field tests is often difficult.
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To evaluate PBAE distribution between the two administration methods and how this might affect transfection efficacy, 12 9L tumor-bearing rats were divided into two groups: a CED group (n = 6) and an intracranial bolus injection group (n = 6).
Similarly, EEG power density of wake during 1st hour after administration was indifferent between two administration.
cTest-retest between two administrations at 12 weeks.
Significant differences were found between the two administration routes.
Patients' satisfaction did not differ between the two administration modes.
Despite encouraging preliminary results, re-examination in inflated samples detected measurement non-equivalence between administration methods on some scale items.
The battle here is not just between two different methods.
Martin Bland, J. & Altman, D. Statistical methods for assessing agreement between two methods of clinical measurement.
Bland, J. M. & Altman, D. G. Statistical methods for assessing agreement between two methods of clinical measurement.
What were the different assumptions between the two administrations that led to such different conclusions?
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