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Thus, a location of KCNE1 between two adjacent subunits at the inter-VSD interface S4-S1 may well account for its impact on Kv7.1 channel gating.
The tryptophan-induced packing perturbations and cysteine engineering studies in S4 suggest that KCNE1 lodges at the inter-VSD S4-S1 interface between two adjacent subunits, a strategic location to exert its striking action on Kv7.1 gating functions.
(c) Packing perturbation and cysteine mutation studies in S4 suggest that KCNE1 lodges at the inter-VSD S4-S1 interface between two adjacent subunits and thereby affects Kv7.1 sensor functions.
In the clockwise rotation model, ATP binding and hydrolysis at the core domain result in repositioning of NTD and core domain and rotation between two adjacent subunits.
Three-dimensional X-ray crystallography shows MIF has a homotrimeric conformation and we have determined that the hydrophobic cavity formed between two adjacent subunits of the homotrimer is required for the pro-inflammatory activity of the molecule.
The binding pocket is formed between two adjacent subunits, and is constituted of the + (or principle) face of one subunit and the − (or complementary) face of the adjacent subunit (e.g., A+A− when between two 5-HT3A receptor subunits).
Similar(54)
The most plausible interpretation of these data is that the bridge formation arises from the interaction between engineered I227C from two adjacent subunits.
We posit that KCNE1 lodges between S1 and S4 segments of two adjacent subunits.
Alternative fittings of two adjacent subunits had tilts and rotations that increased the distance between the N-terminus of one fragment and the C-terminus of the next one.
CaM could embrace helices A and B from the same subunit (cis-binding) or from two adjacent subunits (trans-binding: Fig. 2 41,42.
Monomers make extensive contacts with the two adjacent subunits in the pentamer (subunit A interfaces with B and E, Fig. 3a).
More suggestions(16)
between two adjacent walls
between two adjacent columns
between two adjacent nodes
between two other subunits
between two adjacent circles
between two adjacent peaks
between two adjacent clusters
between two adjacent edges
between two adjacent layers
between two adjacent subchannels
between two adjacent blocks
between two adjacent ridges
between two adjacent lines
between two adjacent frames
between two related subunits
between two adjacent sensors
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