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The plus maze was wiped clean between trials with a 10% alcohol solution.
Looking at the differences in sample size according to type of primary endpoint and funder we found that there is a larger difference in sample size between trials with a dichotomous endpoint compared to a continuous endpoint for publicly funded trials compared to industry funded trials.
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Therefore, it varied slightly between trials, with an overall average and standard deviation of 1.00 ± 0.31 m/s.
The interesting values are the differences within a condition between trials with and without a target.
76 Transfusion triggers varied between trials, with some using a liberal transfusion threshold equal to the restrictive one in other trials, introducing clinical heterogeneity.
We were unable to test whether adverse effects incidence was different between trials with dose titration and trials using a fixed dose.
We were therefore able to determine the effects of acupuncture on sleep quality while reducing undesirable variance due to individual differences, which might be a potential shortcoming in other between-subjects trials with a relatively small sample size.
11 12 We assessed heterogeneity between trials with the χ test for heterogeneity at a significance level of P<0.1.
The distribution of flowering time differed between trials, with six of the eight trials showing a "bell -shaped distribell -shapedwo showing either a flat or apparent bimodistributiontion.
Differences between trials with and trials without exclusions were evident in meta-analyses with a high degree of between trial heterogeneity, but not in meta-analyses with low between trial heterogeneity (P for interaction <0.001).
A meta-analysis of the efficacy of PPV in clinical trials demonstrated a high degree of heterogeneity between trials with little evidence of protection among elderly individuals or adults with chronic respiratory illness, for whom the vaccine was recommended [ 18].
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