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No formal subgroup analyses are planned to look at differences in primary and secondary endpoints between treatment groups within specific groupings based on patient characteristics.
Potential differences between treatment groups within individual trial days were evaluated using t-tests.
To avoid contamination between treatment groups within practices, primary care practices are randomized rather than patients.
Selection bias was minimized by propensity score matching between treatment groups within each cohort.
Mean changes in triglycerides varied across all 6 studies, but were generally comparable between treatment groups within each trial [ 33].
All outcomes were compared between sexes within treatment strata as well as between treatment groups within sex strata.
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Changes in APP processing of holo APP to APP-CTFs (C83, C89 and C99) did not differ between treatment groups or within each APOE genotype (data not shown).
Median age, fraction of males and median days of time interval between diagnosis and begin of treatment were roughly comparable between the treatment groups within each study.
We found no significant differences in frequency of AEs between treatment groups, either overall or within any specific system organ class.
One-way analysis of variance (ANOVA) was used to compare fluorescence intensity or gene expression between different treatment groups (within each clutch).
We did not identify statistically significantly different characteristics such as bone marrow metastasis between the treatment groups within one trial and across all 3 controlled trials.
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