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We now investigated the possible relationships between transcript elongation and genome instability, focusing primarily on genomic loss-associated chromosomal breaks as these were correlated with genes and CFSs.
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Intrinsic terminators between genes can stop transcript elongation and thus prevent read-through transcription.
Bidirectional transcription of two yeast genes causes transcriptional interference between the two RNAII polymerase complexes affecting transcript elongation and termination [9].
DRB thus reversibly blocks new transcript elongation and in effect synchronizes the transcription cycle.
By contrast antisense intronic insertions have little or no effect on transcript elongation and abundance [ 32].
The RNA polymerase II transcription complex may be influenced by factors modifying the transcription complex, factors modifying chromatin, or intrinsic properties of the template and transcript that affect the constant choice between transcription elongation and transcription termination [2] [4].
This suggests that the competition between CBC and the decapping complexes could regulate the balance between transcription elongation and degradation of the nascent transcript.
RNAPII occupancy was higher over exons than adjacent introns, likely reflecting a link between transcriptional elongation and splicing.
The formation of secondary structures by GAATTC may contribute to a block in transcription elongation and reduce the amount of full-length transcript in FRDA [8] [10].
The DBIRD complex functions at the interface between core mRNP particles and RNAPII, affecting local transcript elongation rates and alternative splicing; it is possible that the RNA-binding domain of DBC1 may have a key role on this function.
The many RNA processing events that can occur co-transcriptionally (such as capping, pre-mRNA splicing and 3' end cleavage and polyadenylation [14]), the coupling between transcription and mRNA export, and the possible interrelationship between the promoter state and transcript elongation are all candidates for inclusion in a more detailed model of transcription.
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