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The small number of genes that varied in their tissue specificity (60 genes or 1.1% of the DE genes) indicated that genes with small difference in expression between tissues were more prone to vary between species or be less accurately determined.
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During seed and cone maturation, density differences between different tissues are more evident, for example, the formation of the hard seedcoat (Bramlett et al. 1977).
Overlap analysis between multiple tissues is more desired, while these overlaps are very limited due to the high noise-to-signal ratio of microarray.
"And these days, paper tissues are more and more resistant, so the life-span of tissues on the pistes is increasing.
We hypothesized that expression that is concordant across tissues is more likely influenced by genetic variability than gene expression which is discordant between tissues.
Although miRNAs that are differentially expressed between tumor and normal tissue are more frequently downregulated in tumor tissue [ 7], our study (like others [ 20, 21]) has found that circulating miRNAs that differ in levels between breast cancer patients and controls are more frequently at higher levels in case blood samples.
The difference between tumor and normal tongue tissue are more subtle, but tumor tends to have a lower scattering power than normal tongue tissue.
Conversely, PK genes preferentially expressed in nervous tissue are more conserved between the human and mouse in the coding regions and UTRs, indicating elevated selection pressure on amino acid sequences and on RNA regulatory sequences.
On the other hand, the scenario describing the differential expression between cancer samples vs cancer-free tissue is more complex and not directly comparable with results obtained for cell lines.
Mating between strains that infected the same host tissue is more likely to occur, especially if the sexual reproduction had initiated when the infected host tissue was still attached to the host.
Resection of infarcted tissue is more complicated, and it is difficult to distinguish between already infarcted and potentially salvageable tissue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com