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Although there was a non-significant trend between time to initiation of fluconazole and mortality (Table 4), this was not significant by multivariate analysis.
We statistically analyzed the relationship between time to initiation of surgery and 60-day outcome, examined the change in 60-day outcome associated with each 2 hour delay in surgery initiation and determined a target time for 60-day survival.
Compliance with initial resuscitation bundles and achievement of end points may be important confounding factors in the association between time to initiation of low-dose corticosteroid therapy and mortality.
After adjustment, there remained no association between time to initiation of treatment and race (hazard ratio [HR] 1.04, P = 0.80), marital status (HR 1.00, P = 0.98), age at diagnosis, region, stage at diagnosis (HR 0.87, P = 0.47), or performance status (HR 0.81, P = 0.09; Table 2).
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Therefore, we were able to analyze the association between the time to initiation of low-dose corticosteroid therapy and outcomes.
There is a strong positive correlation between the time to initiation of cART and the size of the proviral reservoir.
Time-dependent Cox regression models were used to adjust for potential confounding factors in the association between the time to initiation of low-dose corticosteroid therapy and in-hospital mortality.
A logistic regression model was used to adjust for potential confounding factors in the association between the time to initiation of low-dose corticosteroid therapy and 28-day mortality.
Cox regression models were used to test for association between patient-related factors and time to initiation of antihyperglycaemic treatment adjusting for other predictors.
To assess whether there was an association between 28-day mortality and the time to initiation of low-dose corticosteroid therapy, the Mantel-Haenszel test was used to examine trends across the quintiles of time.
In logistic regression analysis between time from admission to initiation of surgery and 60-day outcome, time to initiation of surgery was significantly associated with 60-day outcome (adjusted odds ratio 0.31 (per hour delay), 95% CI 0.19, 0.45; P-value <0.0001).
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