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Diagnostic tools able to discriminate between these two variants and between active or latent HHV-6 infection are much needed.
We also examined the relationship between these two variants and HOMA-IR in the Atherosclerosis Risk in Communities (ARIC) study.
There is a strong linkage disequilibrium between these two variants (r=0.95) and only 2.2% of haplotypes showed discordant alleles.
In our study, the PCR primers used for the GH could not distinguish between these two variants of GH.
Conclusion: Our data do not support a causal relationship between these two variants in APOC3 and either HTGC or insulin resistance in middle-aged men and women.
Another difference between these two variants was that mono-, di- and tri- methylated Lysine 4 were also only present in histone H3.2.
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There was only a very small expression difference between these two variant alleles.
However, there is biological plausibility to the relationship between HFE and TF, and ours is not the first study to find synergy between these two variant alleles.
The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5 × 10⁻⁸); rs1229984-ADH1B, p = 7 × 10⁻⁹; and rs698-ADH1C, p = 0.02).
Thus the effect of the CNV could not be distinguished from the effect of either SNP, which is consistent with the strong LD between these three variants.
Overall, there was no significant association between these seven variants and the risk of bilairy tract cancer and stones, although the homozygous genetic variant (TT) of the RXR-β C51T marker was marginally associated with an increased risk of bile duct cancer (OR = 1.67; 95% CI = 0.99 2.84).
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