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In CO, there was no significant activation difference between these two trial types.
Although the treatment effect was not demonstrated in the anti-TNF-naive population in PSUMMIT-2 (unlike PSUMMIT-1), comparison of radiographic findings between these two trial populations is limited by the low progression rate seen across all randomised groups (including placebo) of the PSUMMIT-2 trial relative to placebo-treated patients in PSUMMIT-1.
Based on trial results, participants in the DUIT peer education intervention arm significantly reduced injection related risk behaviors compared to participants in the control condition arm; however, sexual risk reduction did not significantly differ between these two trial arms (Garfein et al. 2007a).
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In addition, there are many differences between these two trials.
The difference in results between these two trials may have occurred due to differences in trial method.
A major difference between these two trials is the proportion of evaluable tumor samples that were p16 positive.
Although there was no statistical heterogeneity between these two trials, both the inclusion criteria and radiation techniques differed.
No significant heterogeneity was found between these two trials (I = 0%, df = 1, χ =0.13, P = 0.72).
While there is significant differences between these two trials, one trial concluded that the osteopathic intervention was similar in effect to a sham intervention, and the other suggests similarity of effect between osteopathic intervention, exercise and physiotherapy.
It is also expected that the global accuracy of the CTC changes, used as a test for early chemoresistance detection, will vary between these two trials, as chemoresistance rates are different between the first and the latest chemotherapy lines.
It is not possible to directly compare the results of QOL data between these two trials due to the differences in measurement tools used, however both trials indicate that some patients obtain symptomatic and QOL benefit which may occur in the absence of objective response.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com