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The pathway specificity was calculated by comparing the P-values between these two target sets.
Subsequent time frequency maps of ISPC between these two target regions and the midfrontal region indeed showed strong connectivity in the theta frequency band around the time of the response (Fig. 3a).
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However, the IDs switch between these two targets once (yellow and light blue).
A Pearson correlation coefficient of -0.847 was calculated between these two targets which suggests that there is some anti-correlation.
For example, serine/threonine-protein kinase PAK7 and AMP-activated protein kinase alpha-2 subunit share 374 active compounds, and 16 of them are drugs; therefore there is a linkage between these two targets, although they are biologically unrelated (belonging to the STE protein kinase group and the CAMK protein kinase group, respectively).
Given that both AdcA and STATc responded to similar stresses (our present data; [ 18]), we examined the possibility of any functional link between these two targets of the osmostress.
In this equation it is seen that if the distance between two targets is, these two targets will have the same phase shifts, but different range shifts.
The lack of independence between the scores for these two targets, coupled with the observed anti-correlation, suggests that different compounds induce phospholipidosis via each of these two targets, which are associated with different mechanisms.
Meanwhile, a strong difference between Ka/Ks ratios for these two targets was also observed in Fig. 3.
Then, another Fourier series is used to represent the difference between the two target profiles.
However, even though the overlap between the two target sets was modest (46%), it was statistically highly significant (p<10−50).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com