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Expression of Nox 1 and 2 however, did not differ between these two mouse strains on this diet (figure 5b, 5c).
The pathways associated with differences between these two mouse models may thus provide information about mechanisms specific to late insulitis and T1D.
However, the onset of a clinical phenotypes is earlier in the 129/Sv than in C57BL/6 background, indicating the existence of genetic modifiers of MFS between these two mouse strains.
Similar percentages of pre-B cells defined by B220 and CD2 staining were observed in both crt−/− and crt+/+ FLC at this time (crt−/−: 10.5±2.1; crt+/+: 9.7±0.9; n = 5), and other B cell developmental stages were not found to differ between these two mouse strains.
Additional experiments are being initiated to identify the basal metabolic differences between these two mouse strains.
The discrepancy between these two mouse models might be due either to different genetic background or to diverse experimental conditions used for primary cultures of neurons.
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"If," Kahn said, "we could figure out the gene [differences] between these two mice we could turn on and off diabetes and metabolic syndrome".
Thus, consistent with the interaction between Tex19.1 and Ubr2, these two mouse null mutants phenocopy each other.
Using IHC it was not feasible to identify any BSE characteristics in either C57BL/6 or RIII mice that were challenged with BSE/scrapie mixtures so there is complete agreement between IHC and Western blot data regarding these two mouse lines.
Both of these mouse models were previously shown to have the Basal-like tumor gene expression phenotypes [ 18, 20], therefore, for this study, we largely focused on copy number commonalities between human Basal-like tumors and these two mouse groups.
MGNC has named these variants Defcr20 and Defcr21, respectively; however the relationship of these peptides between the two mouse strains is not obvious.
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