Sentence examples for between these two modifications from inspiring English sources
Because oxidative stress induces both PCNA NEDDylation and ubiquitination, we sought to clarify the relationship between these two modifications.
In fact, the only fundamental difference between these two modifications is the symmetry of the C-2 chain formed by the respective A-type molecules (I: glide symmetry, II: inversion; see Additional file 1: Fig. S4).
However, the relationship between these two modifications has not been studied in detail.
A number of proteins were identified using each selection criteria (Tables S1 and S2) with strong association between these two modifications suggesting a potential interaction between these two dynamic modifications in many proteins (Table S3).
propose that the dynamic balance between these two modifications is a register of cold exposure.
Consequently, dysregulation of the balance between these two modifications has been implicated in cancer, diabetes, and neurodegenerative disease.
However, it remains to be determined whether the deubiquiylation process is involved in competition between these two modification states.
Lastly, we demonstrated that acetylation at K487 and sumoylation at K490 in PML are mutually exclusive, suggesting a negative crosstalk between these two modification [ 116].
Early studies on nucleosomal response in quiescent fibroblasts demonstrated that, in response to mitogen, histone H3 phosphorylation targeted the fraction of nucleosomes that was sensitive to sodium butyrate induced hyperacetylation, revealing an interesting link between those two modifications [42].
Previous studies have shown that phosphorylation of histone H3 at serine 10 (H3S10P) antagonizes the binding of HP1 to H3K9me, and that the binary phospho-methyl switch between the two modifications is crucial for heterochromatin assembly in humans (Fischle et al., 2003).
The structural difference between the two modifications represents the ordered, head-to-tail arrangement of OH groups located in the center of every other Ca2 triangle in the monoclinic low-temperature symmetry and the disordered arrangement of OH groups, where the head-to-tail and tail-to-head arrangements alternate throughout the channel in the hexagonal high-temperature symmetry.
