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This is consistent with current functional models for eukaryotic DNA polymerases, which alternate between polymerizing and editing modes, as determined by competition between these two active sites for the 3′ end of the DNA.
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These compounds are also useful probes for measuring the distances between the two active sites in the multidomain protein.
Chevalier, B. S., Monnat, R. J. Jr. & Stoddard, B. L. The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites.
The higher efficiency of the fusion protein was due to partial glycerol-3-P channeling between the two active sites.
Despite biochemical evidence for negative cooperativity between the two active sites of the usual TyrRS homodimer, previous structures have captured a crystallographically-imposed symmetric state.
Indeed the cycling performance is intermediate between those of pure In- and Bi-based electrodes, without any beneficial synergy between the two active elements.
Figure 6 Comparison between the two active contour models.
For PRTEE score, there was no significant difference between the two active treatments.
There was no significant difference between the two active treatments (Table 4).
PCF and NAP were significantly better than placebo (P < 0.05), whilst no differences emerged between the two active treatments.
It may be concluded that there is no interaction between the two active substances and MC under the testing conditions.
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