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The boundaries between these three subtypes are often not well defined and also in clinical practice difficult to discriminate.
The presence of shared H2H mutations suggests that reassortments of multiple internal proteins have occurred between these three subtypes.
A comparison of 1997 Hong Kong H5N1 signatures against those of contemporary H9N2 and H6N1 isolates from the same geographical region reveals a dynamic interplay between these three subtypes, in which viral segments appear to have been transferred through reassortments (Figure S2 of the Supplementary Materials S1).
Similar(57)
The similar gene arrangement and location of a partial IS element belonging to the IS6 family, between BotR and orfX1 in these three subtypes also suggests a common ancestry.
We aim to examine the extent to which common genetic variants are shared between these two subtypes.
Although peliosis is much more common in the inflammatory subtype compared to the HNF 1-alpha subtypes (52%% vs. 4%%), there is no notable difference in the risk of clinically manifest bleeding between these two subtypes (16 % vs. 9 %) [33].
This indicated that reassortment events had occurred between these two subtypes of viruses.
Differentiation between these two subtypes required hybridization signals for probes binding to the NS5B region.
We could not find any significant differences in morphological features between these two subtypes in the following three criteria: dendritic field diameter (Figure 3B; p = 0.773, Student's t-test), stratification depth within the IPL (Figure 3C; p = 0.269, Student's t-test), and direction of dendritic bias (Figure 3D; p = 0.841, Mann-Whitney U test), in consistent with a previous report [44].
However, the decreased expression of SATB1 in the late passage K562 cells could up-regulate the expression of γ-globin gene but down-regulate the expression of ε-globin gene, indicating the different regulatory patterns between these two subtypes of K562 cells.
Perhaps this is indicative of signalling between these two subtypes.
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