The interaction between each of these three complexes and calf thymus DNA (CT-DNA) was investigated via spectroscopic techniques and viscosity measurement, which indicated that these complexes could bind to CT-DNA by intercalation.
Furthermore, given that both mTORC1 and mTOCR2 contain mTOR, it is not surprising that many layers of crosstalks might exist between these two complexes.
The changes in geometry between these two complexes and intermolecular interactions such as hydrogen bonding and π⋯π stacking arrangement are discussed.
To demonstrate shuttling of mRNA between these two complexes, investigators utilized specific drugs.
Therefore we propose that the balance between these two complexes determines the stereocilia length gradation within bundle staircases.
Hence, the balance between these two complexes leads to the differential outcomes [ 58].
Assuming that equilibrium exists between these two complexes, when the mTORC1 complex is formed, it could antagonize the formation of the mTORC2 complex and reduce Akt activity [ 44- 46].
Thus it is conceivable that there might be functional relationships between these two complexes, particularly so considering the strong genetic link that has been established.
Vg and YAP motif, despite having a different primary sequence, has all the attributes to form interface 1 and 2. However, one prominent difference between these two complexes is the absence of interface 3 in the Vgll1-TEAD complex.
We experimentally tested and validated four of these newly predicted epistatic interactions between these two complexes in the small-scale E-MAP where the predicted S-score agreed with the measured interaction (all S < -3).
