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An agreement between these simulations and experiments (effective strain and force vs. displacement) should be seen as a validation of the FE model.
Even though outcomes may be influenced by the inferential technique, the error between these simulations and the real signal seen in the test datasets is still a very good indication of how close the datasets are and, consequently, of how the normalisation technique performs.
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But increasing numbers of studies show major differences between the results of these simulations and the actual measured performance of the buildings they are intended to model.
However, no comparison so far has been made between the results of these simulations and existing clinical data.
Hence, it appears unlikely that reasonable differences between the intensification patterns used for these simulations and those that exist in the real world would significantly affect the findings of this study.
Good agreement is observed between the simulations and experiment.
Correcting for that created a model that let scientists to compare apples with apples, which showed the difference between the simulation and observations shrank considerably.
These methods fall in between simulations and formal verification, and they can be applied to larger design descriptions even when their complexity would overwhelm formal analysis.
Ideally, cross validation should be utilized for either method, and the general agreement in these studies between the MD simulations and fluorescence anisotropy results supports the use and findings obtained from each method.
Furthermore, with continuous algorithmic improvement, the availability of faster hardware, and refinement of the available force fields addressing these limitations, the gap between simulations and experiments is rapidly closing, as evidenced by recent studies reporting simulations reaching time scales on the order of microseconds to submilliseconds.
The relationship between computer simulations and experiment, between theories and data, and the role of models in modern particle physics are scientific issues.
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