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Several levels of crosstalk between these pathways and the segmentation clock have been reported.
A crosstalk between these pathways and Wnt/β-catenin signaling in skeletal muscle opens the exciting possibility that organ-selective modulation of Wnt signaling might become an attractive therapeutic target in regenerative medicine and to treat obese and diabetic populations.
Supporting this are recent studies of pathway analyses in other disorders such as Diabetes and Inflammatory diseases [14], [16], where little overlap was seen between these pathways and those reported here.
Though more detailed analyses of the nature of the links (synergistic or parallel) between these pathways and SMN are necessary, we provide strong evidence supporting a connection between BMP signaling and Smn at NMJ by testing additional upstream and downstream elements of this pathway.
Further research is required to verify the proposed link between these pathways and GC MDR.
The relationship between these pathways and gender-specific longevity is not clear.
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Research has already established a connection between many of these pathways and the corresponding cancer type.
We established a link between the activation of these pathways and the different cytotoxicity exerted by PtAcD in healthy and cancerous cells.
Figure 2 shows a GWAS for protein percentage as an example, and displays the relationship between genes studied from these pathways and genome-wide QTL patterns.
Despite our findings, there is a compelling biologic rationale for an association between genetic variation in these pathways and breast cancer risk.
A total of 571 edges (links) connected between any two of these pathways, and these edges were ranked according to the average scores of the Jaccard Coefficient and the Overlap Coefficient (see the Materials and methods section).
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