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One possibility may involve the difference in pharmacological actions (agonist vs. antagonist) between these SSRIs at sigma-1 receptors.
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The reasons underlying this discrepancy between these two SSRIs are currently unclear.
(2004; 2003,) conclude that these SSRIs elevate brain allopregnanolone content at doses below those necessary for inhibition of 5-HT reuptake ex vivo.
After the subjects were pretreated with PRX for 7 days or FLV for 6 days, a single dose of APZ was coadministered with PRX or FLV under fasting conditions at the steady-state plasma concentration of these SSRIs, then repeated oral doses of SSRIs were administered for 14 consecutive days (period II) (Fig. 1).
37, 38 Significantly increased IELT comes at a cost, because several adverse effects are commonly experienced with these SSRIs, including erectile dysfunction, loss of libido, mood changes, and discontinuation syndrome.
The rise in sales reflects patient dependency on these SSRIs: they may have great difficulty stopping even when they taper off the drugs slowly.
The best studied interactions are these between SSRIs and tamoxifen (a Selective Estrogen Receptor Modulator or SERM), which is metabolized by CYP2D6 into its active form endoxifen [ 55].
These results indicate that 5-HT synthesis remains significantly inhibited following a prolonged treatment with a highly selective SSRI at a clinically relevant dose.
We also assessed the association between individual SSRIs and QTc prolongation.
Patterns were similar between individual SSRIs (fluoxetine, citalopram, sertraline and paroxetine, results in the appendix).
There were no significant differences in effectiveness between different SSRIs, which confirmed the findings of Gartlehner et al. [ 33].
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