Genes with at least two times difference in their mRNA levels between these two genotypes were submitted for Student's t-test.
It is noteworthy that many of the sulfur oxidation (Sox) genes, i.e., TTHA1410 (SoxD) to TTHA1417 (SoxB), exhibited a drastic reduction in their mRNA levels (between 5- and 153-fold).
Additionally, the IPN further refined the approach used by Calvano et al by distinguishing between proteins, their activities, and their mRNA levels, as well as by organizing interactions into sub-models representing distinct cell-type specific processes.
If two genes are working together to balance each other's effects, assuming that their activities are correlated with mRNA expression, we can expect the difference between their mRNA expression levels to represent the regulatory balance between them.
The non-parametric Spearman rank correlation was used to examine pair-wise correlations between the mRNA levels and their association with continuous variables (age, smoking, tumor stage/grade).
In the 50 patients analyzed, no correlation was present between FGFR2 mRNA levels in their fibroblasts and the percentage of stroma within the tumor (Spearman's ρ = 0.17, P = 0.23).
Of the 9 shortlisted genes, CENTD1, CEP55 and HELLS, showed a correlation between mRNA levels and their respective copy number status (Fig. 7A).
In general, there is no correlation between mRNA levels and their subsequent protein levels.
In lung carcinoma 95-D cells, EGCG modulated MMP9 expression by preventing the nuclear delocalization of NF-κB [ 33] In general, there is no correlation between mRNA levels and their subsequent protein levels.
We examined the association between JUN mRNA levels and organ-specific metastasis within 82 tumor samples based on a published dataset (GSE2603) (Minn et al., 2005).
