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As far as the other three isoforms are concerned, the association between their expression patterns and other parameters is not very strong.
In this study, we investigated HER-2/neu and VEGF expression in Chinese colon patients and explored whether there was any correlation between their expression patterns.
One of the best-known properties of Hox genes is the spatial and temporal colinearity between their expression patterns and their positions within clusters on a chromosome [ 7].
To gain insights into their functions in plants, we sought to identify histone chaperones from two model plant species and investigated their phylogeny, domain architecture and transcriptional profiles to establish correlation between their expression patterns and potential role in stress physiology and plant development.
The objectives of the present study were to identify the genes that are differentially expressed during natural preclinical scrapie infection in sheep using a CVI custom designed 4x44K ovine microarray and to determine the relationship between their expression patterns and prion-associated lesions.
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No correlation could be established between their expression pattern and evolutionary conservation.
Although there are numerous studies on XTH genes, relationship between their expression pattern and function is still a paradox.
Finally, as the WNT/FZD/sFRP signalling elements are dysregulated in most HCCs, we have been unable to find a specific association between their expression pattern and the occurrence of either TP53 or β-catenin gene mutations, which paradoxically had been shown in previous studies as dichotomizing HCC tumours in different clusters (Laurent-Puig et al, 2001).
The vast quantities of data generated from large-scale expression profiling studies provide a rich ground for exploring the complex and conditional relationships that exist between genes, their expression patterns, and tumor phenotypes.
Another approach often applied to microarray data involves creation of a co-expression network within which each 'node' represents a gene, and 'edges' are created between genes when their expression patterns are significantly correlated.
Our results focused on genes which play a significant role in the most important cellular processes and demonstrated a large difference in their expression patterns between BC and control samples.
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