It should be noted that the diagnosis of bipolar disorder in ICD-10 includes both bipolar disorder I and bipolar disorder II but does not discriminate between the two subtypes, as ICD-10 bipolar disorder is defined as a disorder with at least two mood episodes among which at least one is a hypomanic or a manic episode.
As a result, interference competition for susceptible hosts may occur between the two subtypes, such that one subtype could potentially influence the dynamics of the other [11].
The panel consisted of mainly primary tumours and recurrences, and SAM was used to identify chromosomal regions with significantly different DNA copy number between the two subtypes, but no differences were found.
Since SOX2 mRNA levels were largely higher in SCCs than adenocarcinomas of the lung, we questioned whether a SOX2-related signature can discriminate between the two subtypes of NSCLC.
These were used to discriminate between the two subtypes.
In this pilot study, only HOXA9 appeared to be differentially methylated between the two subtypes.
In boys they found a correlation between the two subtypes of 0.56 and 0.47 for girls.
Across the whole genome, we identified specific genomic alterations between the two subtypes.
Differentially expressed genes between the two subtypes were determined for each platform using the same criteria: (1) > 2-fold change between the two subtypes, and (2) False discovery rate < 5%.
Moreover, the clear association with tumor grade potentially indicates that the molecular differences between the two subtypes have prognostic implications.
This could be done by simply comparing the expression level of a gene between the two subtypes of lung cancer.
