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Two genes (Erdr1 and Traf4) differ between the two mutants in the P4 retina (Figure 1B), while hundreds of genes showed different expression between the two mutant adult retinas (Table S3).
The only significant difference phenotypically between the two mutants was the higher penetrance of abnormal teeth on the mandible in Wise mutants, which we attribute to the fact that the Lrp4 mutation is hypomorphic, whereas Wise is believed to be a null.
Note that the cry1 protein level is not correlated with the global gene expression changes between the two mutants, while HFR1 protein abundance is indeed correlated with the expression profiles in the early stages (1 hour) of photomorphogenesis that are induced by blue light (Figure 2A).
However, differences exist between the two mutants.
However, there are also significant differences between the two mutants.
This is one exception from the general rule of correlated translation behavior between the two mutants.
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We note that culture supernatants from the Δpvl strain had significantly reduced cytolytic capacity by 6 h (LDH release was 58.0±7.9% for wild-type supernatants and 33.8±5.4% for those from the Δpvl strain, P<0.05), but the differential supernatant lysis between the two mutant strains is likely due to the selective overproduction of PVL in CCY media (Fig. 4D) [27], [27].
Several point mutations in the AOX gene, mostly different between the two mutant alleles, have been identified.
In contrast, in muscle, there were no differences in Coq9 mRNA levels between the two mutant models (Fig 4K).
Interestingly, there was essentially no difference in the number of tumors in the duodenum or the jejunum between the two mutant mice (supplementary material Fig. S2A,B).
However, there was no difference in the percentage of large (1−2 mm) ileal polyps between the two mutant mice (Fig. 2C).
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between the two transformants
between the two genes
between the two shifts
between the two clones
between the two engineers
between the two variants
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between the two deployments
between the two people
between the two kings
between the two stories
between the two cases
between the two benches
between the two countries
between the two cops
between the two negotiators
between the two versions
between the two marks
between the two leads
between the two districts
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