The equivalence of the effect on both ligands suggests that this mutation acts independently of ligand type or is mediated by interactions conserved between the two molecules.
Because the total spin between the two molecules is unchanged, the transfer of energy can occur rapidly and efficiently.
Circular dichroism and fluorescence experiments demonstrate that oxidized bovine and murine CH3 have surprisingly similar structures and stabilities, considering the marginal sequence conservation between the two molecules.
The binding site size, in terms of base pairs, for the interaction between the two molecules and DNA was also estimated using non-linear regression analysis.
Opposite partial charges attract one another, and, if two polar molecules are orientated so that the opposite partial charges on the molecules are closer together than their like charges, then there will be a net attraction between the two molecules.
deviation for Cα atoms of 0.248 Å, revealing only slight conformational differences between the two molecules in the flexible loops.
Coloured cells above the main diagonal represent the similarity in bioactivity between the two molecules; those below represent structural similarity.
where V AA and V BB are respective self-overlap volume of the two molecules, and V AB is the overlap volume between the two molecules.
When two molecules differ in size, one can be a substructure of the other, i.e., a subgraph isomorphism between the two molecules exists.
By contrast, the Tanimoto coefficients for two acidic molecules against ethane are the same for a fingerprint, but the properties indicate the differences between the two molecules properly (Fig. 1b).
3-D neighbors were binned according to three indices,,, and, where subscripts 1 and 2 indicate molecules 1 and 2, respectively, determined in step 3a, and is the Q x difference between the two molecules.
