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Only very few publications represent the core interface bridging the gap between the two methodological areas.
ANOVA was used to determine if mean growth rates varied between the two methodological techniques (flasks vs. chambered slides) across the five M. aeruginosa genotypes.
The key difference between the two methodological groups is the use of pathway topology to compute gene-level statistics.
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The two methodological approaches yielded similar conclusions.
The two methodological factors were addressed in the current study.
The three methodological approaches gave consistent and complementary results.
The divergent results between the two studies might reflect methodological issues, such as sample sizes, ethnic differences, inclusion and exclusion criteria, or instruments to assess drug treatment response.
As recommended by van Tulder et al., [ 21] a third reviewer (DU) was used in the event of any disagreement between the two reviewers regarding the methodological quality of a trial.
Two methodological differences between LION and the RIONI study are worth mentioning: the number of evaluated events was 10-fold larger in LION (2099 vs. 210), and IEGMs were interpreted by clinical investigators (LION) rather than three members of an expert board (RIONI).
Popper, however, denies that there are any significant methodological differences between the two.
Agreement between the two reviewers for the assessment of methodological quality was evaluated using the Cohen's kappa statistic [20].
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