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Hunkering down somewhere between the two, half worthy and half unworthy, then?
These sets were chosen to eliminate any dependency in each test between the two half data sets based on linkage disequilibrium.
We first calculated the average difference, d *, between the two half site PWM scores for the set of all known mouse TREs.
For full site p53 REs the grade considers a severe negative impact of a spacer between the two half sites larger than two nucleotides (Fig. 1c).
Such tilt is necessary for dimerization, both due to the already mentioned deeper and larger major groove for the AGAACA half-site (compared to an usual AGGTCA one) as to the larger spacer between the two half sites for GRE as opposed to ERE (4 bp versus 3 bp, respectively).
The structure was further subjected to amplitude weighting (considering the weighted contribution of CTF amplitudes and assuming random orientation of all sub-tomograms) and sharpening (B = 2500, multiplied by the FSC between the two half datasets) to yield the final electron density map presented here.
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Locomotor rhythm generation is based on a combination of intrinsic (persistent sodium current dependent) properties of excitatory RG neurons and reciprocal inhibition between the two half-centers comprising the RG.
The boundary value problem of interest is solved by constructing an appropriate set of multipole functions which satisfy the governing differential equations in each half-space and the boundary conditions along the interface between the two half-spaces.
In vanadium redox flow batteries, an accumulated imbalance of the states-of-charge between the two half-cell electrolytes caused by vanadium ion crossover and gassing side reactions can result in only one half-cell achieving 100% state-of-charge, which is referred to as capacity loss that needs to be corrected online.
During the operation of vanadium redox flow battery, the vanadium ions diffuse across the membrane as a result of concentration gradients between the two half-cells in the stack, leading to self-discharge reactions in both half-cells that will release heat to the electrolyte and subsequently increase the electrolyte temperature.
The exact analytical expressions for the amplitude ratios of the reflected and transmitted waves are shown to depend on the elasticity parameters of the interface between the two half-spaces, in addition to the classical parameters of the bulk of these media.
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