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Exact(15)
Moreover, the two-sample t-statistic modified for correlation between the two duplicates was used.
Rapid neo- or sub-functionalization between the two duplicates would restore the stoichiometric balance and alleviate this gene dosage constrain, thus enhancing gene duplicability.
If the highest FEV1 between the two duplicates was < 20% below the post-saline FEV1 reference, patients progressed to the next highest concentration of AMP.
In subfunctionalization, ancestral functions and/or expression patterns are divided between the two duplicates (Force et al. 1999; Lynch and Force 2000).
Either one copy obtains a new function (neo-functionalization) or the original gene functions are divided between the two duplicates (sub-functionalization).
With a sequence identity between the Atlantic salmon IA and IB regions of approximately 82percentt, recombination may even be occurring between the two duplicates today.
Similar(45)
While the electrophoretic polymorphism is not due to the duplication, the observation of a heterozygous genotype for an inbred strain may well have been due to a polymorphism between the two duplicate copies (modern AKR/J mice have the duplication; Figure 3).
The series was injected in duplicate, which due to the 30 min LC run time resulted in a well-defined 10 h difference between the two duplicate analyses of the same sample.
The few statistically significant differences detected between the two duplicate systems were determined to have small or trivial effect sizes, and their magnitudes to be of little physiological importance.
For the cell line dataset, 78% of the 1,000 most significant genes is reproduced between the two duplicate datasets C1 and C2 when using the intensity analysis, whereas only 73% of the genes is reproduced with the ratio analysis (see Figure 4C).
In terms of the protein interaction network, a gene duplication corresponds to the addition of a node with links identical to the original node, followed by the divergence of some of the now redundant links between the two duplicate nodes; see fig. 1(c).
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