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The dropout rate ('relapse' rate) also differed significantly between the two dose groups.
Dose injection of the repeat dose group was initiated 4 days prior to dosing of the single dose animals so that necropsies occur on the same calendar day for all groups, thus allowing for sharing of control clinical pathology and necropsy data between the two dose regimens.
Moreover, the toxicity rates difference was not significant statistically between the two dose groups.
The primary endpoint ORR had no significant difference between the two dose groups, with a value of 26%.
There was no significant difference in outcome between the two dose levels but the higher dose of 5-FU was associated with more dose reductions and greater toxicity.
Fingolimod at two doses (0.5 and 1.25 mg) showed superior effectiveness in the frequency of relapse with little difference between the two dose groups.
Similar(49)
However, a significant difference between the two doses of dFdC was observed in the profile of cell cycle after 10 h treatment.
There were minimal differences between the two doses of romifidine, and both should be used with care especially in horses with cardiovascular compromise, or when used in combination with other cardiovascular depressant drugs.
No overall difference between the two doses was observed.
The effect of VPA on the NF-кB pathway was dose-dependent as well, and the difference between the two doses of VPA was statistically significant (P < 0.05).
There was a considerable difference between the two NPs and the similar result was detected between the two doses of OVA protein.
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