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This observation suggests there is some functional overlap between the two checkpoint effector kinases.
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If I ran between the two checkpoints five or six times, I could make five miles.
The rules of the race require a mandatory 12 hours of rest to be divided between the four checkpoints along the trail.
However, the early lethality of Chk1-deficient mice and severe checkpoint deficits in derived ES cell cultures argues against a significant degree of redundancy between these two checkpoint pathways in vivo.
Of these 600, many have moved, because the three checkpoints between here and Ashkelon (the closest city in Israel) make what used to be a 40-minute drive, now a 12-hour or impassible journey.
We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between these two checkpoints.
Only officially authorised vehicles are allowed through the three checkpoints.
Data flow during each stage is controlled by the three checkpoints depicted in Fig. 3(b).
Furthermore, the ATM orthologue Tel1 may be involved in this phosphorylation event thus potentially establishing crosstalk between the two apical checkpoint kinases.
Exactly how the substrate binds into this receptor is not yet clear, but the interactions between Cdc20 and two checkpoint proteins in the structure of the Mitotic Checkpoint Complex (Chao et al., 2012) indicate that a KEN-box can bind to the top surface of Cdc20.
Saturday's attack took place in the early afternoon between two checkpoints leading to Jamhuriat Hospital, a 350-bed facility built by China a decade ago.
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