Although the anti-stroke effect mediated by Ex-4 was found to be dose-dependent, it was not linear between the three administered doses.
Heterogeneity of effects between the two trials administering 750 mg acetazolamide daily was moderate (I=44%, P=0.18).
Heterogeneity between the four studies administering acetazolamide 250 mg daily was low (I=15%, P=0.32).
Although the doses of fluid resuscitation with 6% hydroxethyl starch 130/0.4 differed between the two groups, the administered volumes have reportedly only minor effects on parameters of thromboelastography [ 41, 42].
However, this provided the ideal background to reveal a clear synergy between the two drugs when administered together; this cooperative activity mirrored that reported in models of hypoxia-induced PH and patients with the disease (Zhao et al., 2003; Preston et al., 2004; Klinger et al., 2006; Baliga et al., 2008).
The same criteria as above (SAM FDR=10%) was used to identify 119 genes whose expression was different between the response to the two agents administered separately.
The characteristics between the two groups differed in administered type of induction therapy and serologic response before PBSC mobilization (Table 1).
Ten months later, and five months before his death, in a letter written to his editor at Scribner's between the two courses of shock treatment administered to him at the Mayo Clinic in Rochester, Minnesota, the writer tried, alarmingly, to explain what he was doing: Have material arranged as chapters — they come to 18 — and am working on the last one — No 19 — also working on title.
The drug was administered between the two PET scans.
This discrepancy is explained by considering the difference in the amount of mAb administered between the two experiments.
