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Absorption of poorly soluble, slowly absorbed molecules can obviously result in a complete lack of correlation between the total dose deposited in the lung and the resulting systemic exposure.
It is well known that there is a correlation between the total dose of nucleated cells transplanted per kilogram of body weight of the recipient and outcome.
Although there was no definite linear correlation between the total dose and volume reduction rate, the average volume reduction rate was higher in those who received more than 25 Gy.
This was a ratio between the total dose of MTX administered (mgm−2) and the treatment duration expressed in days divided by 7. Treatment duration was calculated from the first day of the first course to the 22nd or 29th day of the last course (respectively for regimens administered every 3 or 4 weeks) (Hryniuk and Goodyear, 1990).
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There was also no overall association between risk and the total dose prescribed and no risk reduction was seen among subjects who used the highest doses of NSAIDs.
We daily evaluated patients and titrated sedatives to the lowest dose needed to maintain a SAS score of 3 to 4. We again found a logarithmic relation between TwPdi and the total dose of piritramide as well as propofol that patients had received at the time of measurement.
This is also reflected in the inverse relationship between graft survival and the total dose of corticosteroids during the same time period.
In addition, a statistically significant dose-response relationship was found between AVN development and the total dose of steroid administered in the first 2 weeks after surgery (p < 0.01 and p < 0.01) (Table 6).
There was a highly significant linear relationship between AUC0− t and the total dose of CYT997 infused (P<0.001; Figure 1A), indicating that the pharmacokinetics of CYT997 were linear over the entire 50-fold dose range investigated in this study (7 358 mg m−2).
Effective doses due to the radiopharmaceutical compounds in the brain PET/CT protocols have been found to contribute between 77 and 88% of the total dose.
In the HRTEM mode (Fig. 2d), typical image exposure times of 0.1 1 s and dose rates between 1 and 50,000 e/Å2s determine the total dose.
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