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This guideline explains that unblinded evaluation is regarded as the appropriate approach in the first round of pathological observations because it 'allows the pathologist to intensely focus the histopathologic evaluation and to find important, and sometimes subtle, differences between the tissues of treated and untreated animals'.
As such transcripts did not show sufficient correlation between the tissues of interest and blood, we chose not to examine them further through pedigree-wide expression profiling in blood.
In plants, pollination and subsequent fertilization rely on an extensive and complex dialog between the tissues of the pistil (both sporophytic and gametophytic) and the pollen tube [ 1, 2].
Post-gastrulation tissue-specific epigenetic modification can also occur at MEs, resulting in differing absolute levels of DNA methylation between the tissues of one individual, but the persistence of the similar magnitude of interindividual methylation variation when the same tissues are compared between different organisms.
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Low cellular uptake of [18F]FMISO in hypoxic cells and slow cellular washout from non-hypoxic tissue limits the contrast between the tissue of interest and the background at early time points post injection [41, 42].
We then called tDMPs for each tissue between the tissue of interest and all the other tissues (Materials and Methods).
For each of the tDMRs we calculated the nearest TSS and calculated for that gene the logFC of expression between the tissue of interest and the other 3 tissues for each of the 4 sets of tDMRs.
These factors include the structural and functional relationships between the various tissues of the barley caryopsis and the timing of the events of germination in the context of industrial malting.
The largest solid aggregates (up to 10 mm in diameter) were in the proximity of the injection site in the stomach serous membrane, between the connective tissues of the abdominal skin, muscles, and peritoneum (Figs. 4a c, 5a c, 6a c, and 8).
The largest agglomerates (up to 10 mm in diameter) were seen in the proximity of the injection place in the stomach serous membrane, between the connective tissues of the abdominal skin, muscles, and peritoneum.
There may be extracellular communication between the ductal tissues of the breast and those of the salivary glands, since the histophysiology is very similar between these two distant tissues [46].
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