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In practice, due to free energy barriers, there is often a wide gap between the time scale of the transformation and the time scale accessible with simulations.
Alas, such contamination was a much bigger problem for the shadowy vehicles that issued asset-backed securities before the crisis.Another concern is any disparity between the time scale of a financial institution's borrowing and lending (called a maturity mismatch if you think it is worrying and maturity transformation if you think it is helpful).
To validate our method we chose to analyze a dataset for which there was a known separation between the time scale of the experiment and the time scale of a biological process of interest.
In the final step of the development of our model, we analyzed the relationship between the time scale of the [Ca 2+] NJ transients resulting from our model and that of the observed Ca 2+ signal shoulder in Figure 1.
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Thus, the inhibitor equilibrates between sites on the time scale of a few minutes, whereas the DTNB reaction occurs on the time scale of 2 hours for half-saturated enzyme.
Patterns of divergence between sibling species, extending the time scale of analysis, showed remarkable heterogeneity among functional regions of gambicin across all three species pairs, with over ten fold reduced divergence in coding as opposed to NC regions.
Our results show that, both in mice and in humans, pazopanib exhibits a dual mechanism of action, and parameter estimation values highlight the inherent difference between mice and humans on the time scale of tumor size response.
Adaptive brain function is characterized by dynamic interactions within and between neuronal circuits, often occurring at the time scale of milliseconds.
The AdEx model can be fit with good agreement to three types of cortical neurons, as can be seen from the comparison between model and experimental traces on the time scale of seconds (two first columns in Fig. 8).
Moreover, we find that the aggregates are highly dynamic in nature, and TO molecules can exchange between the aggregate and the interface at the time scale of microseconds.
SDSL can be used to determine the secondary and tertiary structures of a protein, to reveal the existence of conformational equilibria, to determine structural features of the substates involved, and to determine the time scale of exchange between them.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com