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No differences in dot size or number were found between the three isoforms.
The highly homologous active ERM proteins are phosphorylated on a C-terminal threonine and can be recognized using a specific anti-P-ERM antibody which does not discriminate between the three isoforms.
Again this suggests differences between the three isoforms.
Differences in binding affinities between the three isoforms are dramatic, and lead to these observed differences in lipid levels [ 18].
In contrast, the BB of controls tended to have an equal distribution between the three isoforms, whereas the VL predominantly expressed MHC I and IIa.
Figure 2(A) shows the sequence alignment of the three PI5P4Ks around this G-loop region, emphasizing the clear differences between the three isoforms.
Similar(50)
Furthermore, due to the high mRNA sequence similarities between the two isoforms, an elaborative experimental design is strongly recommended for such studies.
However, detailed analysis of isoform-specific organelle localization and characterization is difficult due to the 93% amino acid identity between the two isoforms.
Small sequence differences between the two isoforms therefore mediate large differences in assembly capacity, even though these two related organelles have a common evolutionarily ancient architecture.
Moreover, a clearer picture emerges to explain how a handful of amino acid substitutions can give rise to subtle differences in ligand binding between the two isoforms.
This inhibition was enhanced by low, but dampened by high, expression levels of L7A and L7B and differences were observed between the two isoforms.
More suggestions(16)
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