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To avoid selection bias, established inclusion and exclusion criteria were defined to reduce differences between the study populations.
The difference in findings between our study and the two prior studies may result from ethnic/genetic differences between the study populations.
Second, the difference from previous studies on GSTM1 in RA may be due to dissimilarity between the study populations.
For a comparison of some demographics between the study populations and the overall Chinese population, see Text S2.
There were no heterogeneity between the study populations (p = 0.09 1.0) using the Mantel–Haenszel method with a generalised linear model.
The difficulty to reproduce eQTL (and other genetic associations) is partly explained by differences between the study populations: different populations have different genetic backgrounds, which may considerably alter the phenotypes associated with a given allele.
Despite some individual differences between the study populations, no significant findings were obtained by heterogeneity testing, and the pooled ORs for rs961616 and rs2297926 both remained above the threshold of significance (Figure 2), thus suggesting MAMDC1 as a candidate gene in SLE susceptibility.
Additionally, part of the increase may be due to differences between the study populations.
Similar(3)
There are, however, clear associations between the study population studied and experimental outcome (Tables 1, 7, 2, 8, 3 and 9).
No significant differences in the distributions of age, sex, size of residential area, or level of education were observed between the study population and the general population in Korea (Table 1).
Other notable differences between the study population examined here and studies in low and middle income countries include high levels of maternal education, relatively low levels of maternal depression, and low rates of child stunting.
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between the study groups
between the study communities
between the study species
between the trial populations
between the study areas
between the study cases
between the study drugs
between the study treatments
between the study pools
between the study phases
between the study arms
between the study years
between the study sites
between the study participants
between the study cohorts
between the study regions
between the study group
between the study designs
between the study variables
between the study periods
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