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Overlapping between the study pools is another limitation.
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Second, the study pool is mammoth and long-term.
For each sample, the expression ratio between the study case and reference pool was determined for each transcript on the microarray.
There was significant heterogeneity in the outcome of duration of antibiotic treatment between the pooled studies.
Owing to the high degree of study heterogeneity between studies, pooled estimates of the strength of associations were not performed.
Any heterogeneity between the studies would not be justified to pool the assessed outcomes.
There was a higher proportion of patients with duration of T2DM of ≤1.5 years in the 20-study pool, compared with the 11-study saxagliptin add-on to metformin pool; otherwise, no notable differences were observed between the pooled populations.
Tests revealed no statistical heterogeneity between the studies, suggesting that it would be appropriate to pool the effect sizes.
On the other hand, some reviewers who pool data appear to disregard differences between the studies.
However, in an actual association study, pooled DNA estimates are not compared within and between pools of the same individuals but rather between different pools consisting of different individuals.
The random effects model was used for meta-analyses (to guard against the effects of between-study heterogeneity), pooled relative risks (RR) and 95% CI were calculated.
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